Whitehead Institute for Biomedical Research
Whitehead Institute for Biomedical Research
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Making a big switch to plant biology | A Day in the lab
Follow graduate student and plant scientist Carly Martin as she spends a typical day working in Whitehead Institute Member Mary Gehring's lab.
Read about Carly's work and follow the Day in the Lab series on our website: wi.mit.edu/news/day-life-graduate-student-and-plant-scientist-carly-martin
Переглядів: 264

Відео

Delivering Therapeutic Proteins into Cells Using Biological Nanoparticles
Переглядів 302Місяць тому
Whitehead Fellow Aditya Raguram discusses how biological nanoparticles can be designed to safely and efficiently deliver therapeutic proteins into cells within the body. He describes how these delivery technologies could enable new therapies for genetic disorders, cancer, and other diseases. Find upcoming events on our website, wi.mit.edu/events
Diversity in blood cell types diminishes with age | Research highlights
Переглядів 902 місяці тому
Catch up on exciting discoveries at Whitehead Institute. Researchers in the Cheeseman lab have created a new experimental system to better understand how protein complexes assemble to aid in cell division. Weissman lab researchers are tracing the lineages of blood cells, an approach that sheds light on how blood production changes as we age, and how those changes influence disease risk. Researc...
X and Y chromosomes' effect far beyond the reproductive system | Research highlights
Переглядів 2022 місяці тому
Catch up on exciting discoveries at Whitehead Institute. New work from the Yamashita lab shows that asymmetrical cell division, specifically in germline stem cells (GSC), conserves enough ribosomal DNA to be passed on to future generations. Spatial maps constructed by Reddien lab members reveals that when planarians regenerate, differentiating stem cells are spatially heterogeneous, with adjace...
Axolotls are pros at regrowing limbs | Unusual Labmates
Переглядів 4 тис.2 місяці тому
Few axolotls live in the wild, but millions can be found in laboratories worldwide. Whitehead Institute graduate student Conor McMann is one of many researchers studying this salamander's amazing ability to regrow body parts, from tails and limbs to even pieces of its spine and brain. McMann seeks to understand whether the rules of regeneration in axolotls can be generalized across other specie...
Introducing Valhalla Fellow Allison Hamilos
Переглядів 2515 місяців тому
Meet Allison Hamilos, one of the newest members to the Whitehead Fellows Program. The Hamilos lab uses a variety of approaches - including electrophysiology, optogenetics, machine learning and computational modeling - to study the neural circuits disrupted in neurological and psychiatric disease. The Whitehead Fellows Program provides highly talented and accomplished recent PhDs the opportunity...
Introducing Whitehead Fellow Aditya Raguram
Переглядів 3535 місяців тому
Meet Aditya Raguram, one of the newest members to the Whitehead Fellows Program. The Raguram Lab studies how to deliver therapeutic molecules into cells within the body. The Whitehead Fellows Program provides highly talented and accomplished recent PhDs the opportunity to launch their own research programs, instead of working as postdoctoral researchers in a senior scientist’s lab. Since its fo...
How oxygen-intolerant microbes navigate an oxygen-filled world
Переглядів 2206 місяців тому
Despite living in an oxygen-filled world, oxygen-intolerant bacteria are abundant within us and around us: in the human microbiome, the soil, and marine environments. Whitehead Fellow Lindsey Backman discusses her lab’s mission to determine molecular tactics that enable bacteria to cope with varying levels of oxygen and oxidative stress. She explains how studying these protective mechanisms cou...
Whitehead Institute: a closer look
Переглядів 7018 місяців тому
Whitehead Institute, located in Cambridge, Massachusetts, is world-renowned for its fundamental biomedical research. Our mission is to forge new frontiers in science, uncovering insights today that unlock the potential of tomorrow. In this video, learn about the Institute's mission and values, and meet some of the researchers who are pursuing a diverse set of scientific questions in areas inclu...
Fall/Winter 2023 | Whitehead Institute Research Highlights
Переглядів 386Рік тому
Catch up on exciting research and discoveries at Whitehead Institute. This video covers the Cheeseman lab's ambitious effort to reveal the function of essential human genes; research from the Jain lab illuminating how RNA aggregates may be deleterious to cell function in repeat expansion disorders; a gene involved in germline stem cells' immortality uncovered by the Yamashita lab; and new resea...
Repeat expansion disorders - how RNA may gum up the works
Переглядів 888Рік тому
What happens when an RNA molecule contains too many repeats of the same short sequence of bases, or RNA building blocks? Whitehead Institute Member Ankur Jain and graduate student Michael Das explore how such repeats may contribute to neurodegeneration. To learn more about neurobiology research at Whitehead Institute, visit wi.mit.edu
Searching for genes linked to opioid use disorder (OUD)
Переглядів 337Рік тому
Figuring out the genetic risk of developing opioid use disorder (OUD) is difficult, because there are many genes, and combinations of genes, that can lead to OUD in any one person. Whitehead Institute Member Olivia Corradin is using a new approach to narrow in on important risk genes. To learn more about neurobiology research at Whitehead Institute, visit wi.mit.edu
The importance of broad scientific literacy: lessons from covid, climate change and more
Переглядів 265Рік тому
Whitehead Institute Director Ruth Lehmann and award-winning science writer Carl Zimmer discuss why broad science literacy is important, especially in the face of climate change and the COVID-19 pandemic. Find upcoming events on our website: wi.mit.edu/events
Why sex matters in health and disease
Переглядів 627Рік тому
David Page’s lab studies the genetic differences between males and females and the biological and medical ramifications of these differences. At the core are the sex chromosomes: females have two X chromosomes, while males have an X and a Y. The Page Lab has overturned the long-held view that the influence of sex chromosome constitution (XX vs. XY) is restricted to the reproductive tract. Intri...
The Patient Parasite: How Toxoplasma has Taken Over the World
Переглядів 1,1 тис.Рік тому
Whitehead Institute Member Sebastian Lourido discusses his lab's latest findings on how parasites establish long-lived chronic infections in their hosts.
Searching for rejuvenation cocktails using CRISPR technology, Perturb-seq
Переглядів 480Рік тому
Searching for rejuvenation cocktails using CRISPR technology, Perturb-seq
Unusual Labmates: C. elegans
Переглядів 2,2 тис.Рік тому
Unusual Labmates: C. elegans
Using Chemical and Biomedical Engineering to Advance Biomedicine
Переглядів 232Рік тому
Using Chemical and Biomedical Engineering to Advance Biomedicine
Spring/Summer 2022 Research Highlights | Whitehead Institute
Переглядів 435Рік тому
Spring/Summer 2022 Research Highlights | Whitehead Institute
"Mapping" the body with single-cell RNA sequencing
Переглядів 987Рік тому
"Mapping" the body with single-cell RNA sequencing
Genomic Integration of the SARS-CoV-2 Virus and the Potential Relevance for the Course of COVID-19
Переглядів 9742 роки тому
Genomic Integration of the SARS-CoV-2 Virus and the Potential Relevance for the Course of COVID-19
Preparing for the next generation: how maternal information passes to progeny
Переглядів 3152 роки тому
Preparing for the next generation: how maternal information passes to progeny
Mysteries of Animal Hibernation presented by Siniša Hrvatin, Member, Whitehead Institute
Переглядів 6282 роки тому
Mysteries of Animal Hibernation presented by Siniša Hrvatin, Member, Whitehead Institute
The Code Breaker: A Conversation with Jennifer Doudna
Переглядів 1,2 тис.2 роки тому
The Code Breaker: A Conversation with Jennifer Doudna
Introducing Whitehead Institute Member Siniša Hrvatin
Переглядів 9642 роки тому
Introducing Whitehead Institute Member Siniša Hrvatin
Fall/Winter 2021 Research Highlights | Whitehead Institute
Переглядів 2022 роки тому
Fall/Winter 2021 Research Highlights | Whitehead Institute
Using philanthropy to spark government innovation in food access, education, and guaranteed income
Переглядів 782 роки тому
Using philanthropy to spark government innovation in food access, education, and guaranteed income
Communicating About Science in a World of Misinformation with Linda Henry and Rick Berke
Переглядів 1362 роки тому
Communicating About Science in a World of Misinformation with Linda Henry and Rick Berke
CRISPRoff | Tool and Method Development at Whitehead Institute
Переглядів 3362 роки тому
CRISPRoff | Tool and Method Development at Whitehead Institute
Morphogen gradients in a dish | Tool and Method Development at Whitehead Institute
Переглядів 4682 роки тому
Morphogen gradients in a dish | Tool and Method Development at Whitehead Institute

КОМЕНТАРІ

  • @FREEDOTYOU
    @FREEDOTYOU 16 днів тому

    go to the cell rejuvination video and turn comments on ,turning comments off on any video you produce is a big mistake you may glean vital informatiin that may crack the code ,i already have some ideas that i guarantee have not been looked at. i might have figured out the missing piece to your puzzle first off im nobody and require no credit for it ,the value brought to humanity is reward enough

  • @christisking7911
    @christisking7911 21 день тому

    💪🔥🙏👍👍🎉🎉👀👀👀👍❤️🙏🔥🔥💪💪💪🔥🔥💪💪🔥🔥🔥🔥🔥

  • @christisking7911
    @christisking7911 21 день тому

    👀🙏🙏👍💪💪🔥🔥🔥❤️❤️🔥🔥🔥🔥🙏🙏🔥🔥🔥💪💪🔥🔥💪💪🔥🔥🔥💪💪🔥🔥💪💪🔥🔥🔥🔥💪💪

  • @belugaprincess
    @belugaprincess 4 місяці тому

    What types of cells do you use? HeLa or just random cells?

  • @pedagogy8248
    @pedagogy8248 11 місяців тому

    more ❤

  • @DietArchitect
    @DietArchitect Рік тому

    Dr. Lourido-I've been studying toxoplasma, so I found this really interesting and helpful. Thanks so much! -Joan Tendler

  • @surfreadjumpsleep
    @surfreadjumpsleep Рік тому

    Wish I had been a scientist instead of a silly "computer" scientist. It's a scam! There is no science in computer science!

  • @wanedanesh
    @wanedanesh Рік тому

    1:50 Planaria, belongs to Phylum Platyhelminthes of kingdom Animalia... It has the highest regeneration power in entire animal kingdom.

  • @sayulitalyfe5299
    @sayulitalyfe5299 Рік тому

    I agree w making these weirdos not being able to reproduce... we got to start eliminating these people w mental health issues by making sure they cant reproduce. Keep up the good work children hospital

  • @SPA926
    @SPA926 Рік тому

    Waiting for the chance to meet her

  • @brandonmalady4425
    @brandonmalady4425 Рік тому

    Incredible science communication right here. Would love to do a collaboration with my podcast "Goggles Off"

  • @Mandy-Lane
    @Mandy-Lane Рік тому

    nnnnice!! very nice story

  • @ysosirius2886
    @ysosirius2886 2 роки тому

    why didn't any of these scientists take gene therapy for CV19?

  • @amrisharora6246
    @amrisharora6246 2 роки тому

    It shocks me how a 550 million Kaleidoscope biosciences was destroyed overnight, lots of hard earned money gone here… I hope you can do something for KLDO investors?

  • @JudithTheROSE
    @JudithTheROSE 2 роки тому

    Parasites 🦠 viral load

  • @surfreadjumpsleep
    @surfreadjumpsleep 2 роки тому

    I'm looking forward to hearing more from Dr. Hrvatin.

  • @kellikelli4413
    @kellikelli4413 2 роки тому

    You say there are too many people. Isn't disease one of the "natural selection" answers to that problem. Unless making money $ on diagnostics and lab 🔬 created medicines is the real goal. Seems to me if people are really concerned about cancer they would stop the causes of it. Healthy people in healthy surroundings, eating healthy natural foods don't get cancer.

    • @kellikelli4413
      @kellikelli4413 2 роки тому

      I have to disagree with your suggestions. Stopping people from smoking 🚬 has not reduced the incidence of lung cancer. Vaccines do not make people healthier. Reducing food and beverage additives would improve people's health. Reducing air pollution also would improve health. You're on the wrong track (in my opinion). And your ideas infringe on people's rights.

  • @kellikelli4413
    @kellikelli4413 2 роки тому

    Why do we need living machines..?

  • @TheCD45
    @TheCD45 2 роки тому

    A great new recruit by the Whitehead!!!

  • @etewis87
    @etewis87 2 роки тому

    Science Dave Grohl

  • @congsonpham9568
    @congsonpham9568 2 роки тому

    This video is useful, now I can understand how we approach the lineage tracing with single-cell sequencing. Thank you!

  • @crumpfyllc5571
    @crumpfyllc5571 2 роки тому

    As a Marfan Syndrome Patient I hope it will change our FBN1 Gene.

  • @naturelover472
    @naturelover472 2 роки тому

    Thank U❤

  • @KJKP
    @KJKP 3 роки тому

    As autophagy counters tumors, what research is being done to evaluate the effect of dietary actions like ketosis or intermittent fasting, both of which have been shown to dramatically activate autophagy?

  • @KJKP
    @KJKP 3 роки тому

    Interesting. This concept of DIFFERENT proteins in the membrane of tumor cells than exist in normal cells was boggling me in the first minutes. Then, he says it is aberrant and little is known. So, okay. Explains why I never heard of this in college biology. But, if little is known, how does the scientific community facilitate the recognition of said aberrant (unique, hopefully) proteins on tumor cells?

    • @KJKP
      @KJKP 3 роки тому

      Okay, around 35:45 he explains this is the question his lab is working to answer. So, the question I asked is the one he wanted us all to recognize. Nice speaking skills.

  • @BanBiofuels
    @BanBiofuels 3 роки тому

    *Imagine a beautiful green hill that has been covered in solar panels made with all kinds of toxic exotic substances, and giant Godzilla sized windmills built in China with energy from coal fired power plants and transported in oil powered ships all the way to America. Imagine the huge amount of concrete needed to site each windmill, and how much it will cost to remove one day. Ask yourself, how much energy can that hill produce on a still, windless night?* Think of all the people making money and gaining political power by scaring the public with climate misconceptions from the early 1800s. The greenhouse gas theory was born before the invention of weather balloons, satellites, and space probes, so it is based on wild conjecture before there was evidence to prove it. Back then we had no ancient ice core records that today show us that temperature drives atmospheric carbon dioxide levels, but carbon dioxide levels do not drive temperature. The warmer it gets, the more carbon dioxide is released from our oceans. The cooler it gets, the more our oceans absorb carbon dioxide. Over the past 420 million years, carbon dioxide levels have fluctuated between 300 and 2200 parts per million, yet life flourished, our oceans never turned into acid, and our forests did not die due to heat. Satellite and space probe data tells us we can accurately predict the long term average baseline surface temperatures of any rocky surfaced planet or moon in our solar system by knowing just two strategic facts: their distance from the Sun and their atmospheric pressure. This proves that a planet’s specific atmospheric composition of gases is irrelevant to temperature. What regulates temperature is the amount of solar energy a planet receives and the amount of atmospheric mass that surrounds the planet. The FORCE of gravity on atmospheric mass creates a thermal enhancement that keeps Earth’s oceans from freezing to the equator. These facts tell us there is no greenhouse gas effect anywhere in our solar system. For the fascinating scientific details, please Google *The Renewable Energy Disaster + Christopher Calder + 50webs*

  • @KJKP
    @KJKP 3 роки тому

    At 5:55, she meant to say, “to prevent viruses from invading bacteria.”

    • @kellikelli4413
      @kellikelli4413 2 роки тому

      Bacteria are actually the more resilient of the two, since they can live inside and outside of bodies ~ viruses can't.

  • @campina9143
    @campina9143 3 роки тому

    amazing, stunning... wow

  • @leeondene
    @leeondene 5 років тому

    Still the same conversations been had maybe some progression of course but we still don't have kinder treatments that work on the metabolism of cancer Stem cells

  • @stuartcleary1682
    @stuartcleary1682 5 років тому

    the most effective treatments for Cancer stem cells have been found to be mostly from natural products; sulphurofane, reveratrol, curcumin, zingerol from ginger... some 25+ phyto chemicals use with DMSO as a targeted carrier.

    • @sempfi22
      @sempfi22 5 років тому

      Iodine is the biggest cancer treatment. At least 2 billion people around the world are deficient in iodine. Watch lectures from Dr Jorge Flechas and Dr David Brownstein, they talk about the link of a number of diseases caused by a lack of iodine. Also, read "The Iodine Crisis" by Lynne Farrow. She talks about the history of iodine, why we are deficient, and how she and many other people have cured their diseases with iodine. Fluoride and Bromine are what is killing us, because we are consuming so little of iodine, that the body is confusing fluoride and bromine for iodine.

  • @brcarter1111
    @brcarter1111 6 років тому

    Everyone here in cancer research needs to read "Tumor-Derived Exosomes and Their Role in Tumor-Induced Immune Suppression". Absolutely massive discovery in cancer pathology recently. It seems cancer cells are releasing small, virus like particles that can drive biological change in recipient cells, which include stromal cells, other cancer cells, and especially immune cells. These bodies have been shown to contain viral elements, OCT4 and other pluripotency genes, both MHC I and II molecules from cancer cells, CD95L, and many oncogenes. These bodies have been shown to grossly disregulate and even kill effector immune cells.

  • @MARPSTE
    @MARPSTE 7 років тому

    where is part I of this talk? A link would be great

  • @GGANA19
    @GGANA19 7 років тому

    RIP to an extraordinary scientist...

  • @alz123alz
    @alz123alz 7 років тому

    Beautiful informative lecture.Thank you for your book, the biology of Cancer.

  • @alz123alz
    @alz123alz 7 років тому

    SAD SAD SAD, PATHOLOGISTS COULD HAVE EXPLAINED CANCER STEM CELLS OVER FORTY YEARS AGO. EXFOLIATIVE CYTOLOGY IS BASED ON STEM CELL SPECIALIZATION, GROWTH AND PROLIFERATION ABOVE THE BASEMENT MEMBRANE.

  • @binzhaoscience7537
    @binzhaoscience7537 8 років тому

    I like Bob's sense of humor ! A number of lectures showed that he preferred to save time for updating his work to the audiences other than letting the host give opening introduction of his fruitful achievements.

  • @tonywang7734
    @tonywang7734 9 років тому

    EMT is now well known to be correlated to the production of CSCs. However, something to keep in mind is that EMT might only cause the adoption of SC markers: CD24/CD44, SC gene expression, morphology, but whether the cells themselves are actually stem cells in vitro and in vivo remains to be tested. Something else to think about is if EMT creates stem cells from epithelial breast cancer cells and mesenchymal (not stem) cells from epithelial cells in development, what caused the obvious difference. Where does the parallel end?

    • @jordantaylor276
      @jordantaylor276 9 років тому

      Tony Wang Actually, I wonder if you could clarify. Almost any definition of mesenchymal cells includes 'stem' or at least multipotency as a part, so I've always been confused about this distinction between cancer cells having undergone EMT, and CSCs. What's up with that?

    • @brcarter1111
      @brcarter1111 6 років тому

      difficult to say if EMT is causative or symptomatic of CSC transformation.

  • @sumerpatil22
    @sumerpatil22 9 років тому

    Can someone please provide the link for the research article referred at 07:50 ? The reference mentioned below figure is not readable. Thank you :)

  • @fearlessonmyheart
    @fearlessonmyheart 10 років тому

    Where can I found the papers swowed ?

  • @vijayinvictus
    @vijayinvictus 10 років тому

    seeing this i have got all d symptoms i just wish i die but not of this esp.

  • @vanderbilt4918
    @vanderbilt4918 11 років тому

    See that's interesting. I'm a year shy of earning my PharmD, and the thought of doing an oncology research Master's on the side has tickled my mind over the last couple of years. For me it very much depends on how promising the prospective breakthroughs look over the next couple of decades or so -- can you comment a little bit on this for me as a Cancer Biology major? I would really appreciate it. Thanks.

  • @Lindibigwi
    @Lindibigwi 11 років тому

    Actually, I'm graduating this year from Cancer biology Master's and I'm keen to go ahead with a PhD

  • @sasastanimirovic8765
    @sasastanimirovic8765 11 років тому

    R.Weinberg is a primus inter pares.

  • @vanderbilt4918
    @vanderbilt4918 11 років тому

    Are you currently by any chance a cancer researcher yourself?

  • @Lindibigwi
    @Lindibigwi 11 років тому

    However, R. Weiberg is the origin of my interest in cancer research (more precisely his "hallmarks of cancer, 2000")+all lab directors should be like him towards their students. Their work on EMT is interesting.

  • @Lindibigwi
    @Lindibigwi 11 років тому

    I still have a lot to learn+ there are still things I don't get, but to me, "cancer initiating cells" are a consequence (=agressiv evolution) of cancer but definitly not the origin of it. The name they give to these cells is the only new concept but the phenotype of these cells could not have been a mystery for so long...

  • @sameerdixit2561
    @sameerdixit2561 12 років тому

    Just amazing, how in 1 hr 19 mins I got to know what i was working on for over a month!!

  • @PrinceofHope1
    @PrinceofHope1 12 років тому

    How I wished I was taking 7.012 in MIT (though I was so much younger then)